2-[[2-(2-甲氧基乙氧基)乙基-(2-甲氧基乙基)氨基]甲基]噻吩并[3,2-d]噻吩-5-磺酰胺合成路线 （共 14 条）
反应条件
1: concd. NH4OH / acetone / 1.5 h 2: 2.10 g / p-toluenesulfonic acid / acetone / 1 h / Ambient temperature 3: 1.) HCl, 2b.) 4 A sieves / 1.) methanol, 10 min, 2a.) 24 h, 2b.) 6 d 4: 1.) NaCNBH3, 2.) concd. HCl / 1.) MeOH, 48 h, 2.) THF, reflux, 45 min View Scheme
参考文献
Prugh; Hartman; Mallorga; McKeever; Michelson; Murcko; Schwam; Smith; Sondey; Springer; Sugrue
Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1805 - 1818
反应条件
1: 2.10 g / p-toluenesulfonic acid / acetone / 1 h / Ambient temperature 2: 1.) HCl, 2b.) 4 A sieves / 1.) methanol, 10 min, 2a.) 24 h, 2b.) 6 d 3: 1.) NaCNBH3, 2.) concd. HCl / 1.) MeOH, 48 h, 2.) THF, reflux, 45 min View Scheme
参考文献
Prugh; Hartman; Mallorga; McKeever; Michelson; Murcko; Schwam; Smith; Sondey; Springer; Sugrue
Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1805 - 1818
反应条件
1: 1.) HCl, 2b.) 4 A sieves / 1.) methanol, 10 min, 2a.) 24 h, 2b.) 6 d 2: 1.) NaCNBH3, 2.) concd. HCl / 1.) MeOH, 48 h, 2.) THF, reflux, 45 min View Scheme
参考文献
Prugh; Hartman; Mallorga; McKeever; Michelson; Murcko; Schwam; Smith; Sondey; Springer; Sugrue
Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1805 - 1818
反应条件
1: 1.) HCl, 2b.) 4 A sieves / 1.) methanol, 10 min, 2a.) 24 h, 2b.) 6 d 2: 1.) NaCNBH3, 2.) concd. HCl / 1.) MeOH, 48 h, 2.) THF, reflux, 45 min View Scheme
参考文献
Prugh; Hartman; Mallorga; McKeever; Michelson; Murcko; Schwam; Smith; Sondey; Springer; Sugrue
Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1805 - 1818
