3-氨基-6-[4-[[2-(二甲基氨基)-1-甲基乙基]磺酰基]苯基]-N-苯基-2-吡嗪羧酰胺合成路线 （共 4 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in 1,4-dioxane; water T=150°C; Suzuki coupling; 0.5 h; Microwave irradiationInert atmosphere;
参考文献
Charrier, Jean-Damien; Durrant, Steven J.; Golec, Julian M. C.; Kay, David P.; Knegtel, Ronald M. A.; MacCormick, Somhairle; Mortimore, Michael; O'Donnell, Michael E.; Pinder, Joanne L.; Reaper, Philip M.; Rutherford, Alistair P.; Wang, Paul S. H.; Young, Stephen C.; Pollard, John R.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2320 - 2330
反应条件
1.1: N-bromosuccinmide / acetonitrile / 18 h / 20 °C 2.1: lithium hydroxide hydrate / methanol; water / 2 h / Reflux 3.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / dimethyl sulfoxide / 0.5 h 3.2: 18 h / 20 °C 4.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere View Scheme
参考文献
Charrier, Jean-Damien; Durrant, Steven J.; Golec, Julian M. C.; Kay, David P.; Knegtel, Ronald M. A.; MacCormick, Somhairle; Mortimore, Michael; O'Donnell, Michael E.; Pinder, Joanne L.; Reaper, Philip M.; Rutherford, Alistair P.; Wang, Paul S. H.; Young, Stephen C.; Pollard, John R.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2320 - 2330
反应条件
1.1: lithium hydroxide hydrate / methanol; water / 2 h / Reflux 2.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / dimethyl sulfoxide / 0.5 h 2.2: 18 h / 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere View Scheme
参考文献
Charrier, Jean-Damien; Durrant, Steven J.; Golec, Julian M. C.; Kay, David P.; Knegtel, Ronald M. A.; MacCormick, Somhairle; Mortimore, Michael; O'Donnell, Michael E.; Pinder, Joanne L.; Reaper, Philip M.; Rutherford, Alistair P.; Wang, Paul S. H.; Young, Stephen C.; Pollard, John R.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2320 - 2330
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / dimethyl sulfoxide / 0.5 h 1.2: 18 h / 20 °C 2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere View Scheme
参考文献
Charrier, Jean-Damien; Durrant, Steven J.; Golec, Julian M. C.; Kay, David P.; Knegtel, Ronald M. A.; MacCormick, Somhairle; Mortimore, Michael; O'Donnell, Michael E.; Pinder, Joanne L.; Reaper, Philip M.; Rutherford, Alistair P.; Wang, Paul S. H.; Young, Stephen C.; Pollard, John R.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2320 - 2330
