2-甲基-5三氟甲基-2H-吡唑-3-羧酸合成路线 （共 8 条）
反应条件
sodium bromide in acetic acid
参考文献
Nissan Chemical Industries, Ltd.
Patent: US5053517 A1, 1991 ;
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 2 h; 2: With carbon dioxide in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - 20°C; 2 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
WO2007/43677 A1, ;
Page/Page column 486-487 ;
反应条件
1: 1-methyl-3-trifluoromethylpyrazol With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile T=20°C; 0.0833333 h;
参考文献
Fustero, Santos; Roman, Raquel; Sanz-Cervera, Juan F.; Simon-Fuentes, Antonio; Cunat, Ana C.; Villanova, Salvador; Murguia, Marcelo
Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3523 - 3529
反应条件
1: With sodium hydroxide 24 h; 2: With hydrogenchloride; water T=0°C;
参考文献
Li, Feng; Nie, Jing; Sun, Long; Zheng, Yan; Ma, Jun-An
Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6255 - 6258
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: sodium hydroxide / 24 h 2.2: 0 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 24 p. 6255 - 6258
反应条件
sodium hypochlorite; acetic acid in water T=20°C; 16 h;
参考文献
Fustero, Santos; Roman, Raquel; Sanz-Cervera, Juan F.; Simon-Fuentes, Antonio; Cunat, Ana C.; Villanova, Salvador; Murguia, Marcelo
Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3523 - 3529
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
IRM LLC; AZIMIOARA, Mihai; COW, Christopher; EPPLE, Robert; LELAIS, Gerald; MECOM, John; NIKULIN, Victor
Patent: WO2011/44001 A1, 2011 ;
Location in patent: Page/Page column 34-35 ;
WO 2011/044001 A1
