1: 1H-Indole-5-carboxylic acid With sodium hydride in N,N-dimethyl-formamide 0.416667 h; 2: methyl iodide in N,N-dimethyl-formamide 18 h; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 25 p. 4416 - 4430
1: 2 h / 130 °C / Neat (no solvent) 2: triethyl borane; oxygen; N-ethylpiperidinium hypophosphite / 1,4-dioxane; hexane / 2 h / 73 °C / Air atmosphere View Scheme