N-叔丁氧羰基-3-(4-联苯基)-D-丙氨酸合成路线 （共 4 条）
反应条件
dipotassium hydrogenphosphate; formic acid; Pd(OAc)2(2-amino-4,6-dihydroxypyrimidine disodium salt)2 in water T=37°C; Suzuki-Miyaura coupling; 4 h;
参考文献
Chalker, Justin M.; Wood, Charlotte S. C.; Davis, Benjamin G.
Journal of the American Chemical Society, 2009 , vol. 131, # 45 p. 16346 - 16347
反应条件
dipotassium hydrogenphosphate; formic acid; Pd(OAc)2(2-amino-4,6-dihydroxypyrimidine disodium salt)2 in water T=37°C; Suzuki-Miyaura coupling; 4 h;
参考文献
Chalker, Justin M.; Wood, Charlotte S. C.; Davis, Benjamin G.
Journal of the American Chemical Society, 2009 , vol. 131, # 45 p. 16346 - 16347
反应条件
sodium hydroxide in tetrahydrofuran; methanol Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1689 - 1700
反应条件
1: 97 percent / triethylamine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride, hydroxybenzotriazole / CH2Cl2 / 16 h / Ambient temperature
2: 100 percent / LiAlH4 / diethyl ether / 0.33 h / 0 °C
3: 78 percent / CH2Cl2 / 16 h / Ambient temperature
4: 9.5 percent / H2 / 10percent Pd/C / ethanol / 6 h / 2585.7 Torr
5: 95 percent / HCl (gas) / CH2Cl2 / 5 h / Ambient temperature
6: pyridine / CH2Cl2 / 16 h / Ambient temperature
7: toluene / 1 h / 80 °C
8: HCl (gas) / CH2Cl2 / 16 h / Ambient temperature
View Scheme
参考文献
Ksander, Gary M.; Ghai, Raj D.; deJesus, Reynalda; Diefenbacher, Clive G.; Yuan, Andrew; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1689 - 1700
