N-[(1,1-二甲基乙氧基)羰基]-3,5-二碘-L-酪氨酸甲酯合成路线 （共 9 条）
反应条件
IPy2BF4 in dichloromethane T=20°C;
参考文献
Chalker, Justin M.; Wood, Charlotte S. C.; Davis, Benjamin G.
Journal of the American Chemical Society, 2009 , vol. 131, # 45 p. 16346 - 16347
反应条件
1: methanol; L-4-hydroxy-3,5-diiodo-phenylalanine With thionyl chloride T=0°C; 2 h; Reflux; 2: With N-ethyl-N,N-diisopropylamine in dichloromethane T=0°C; 3: di-tert-butyl dicarbonate in dichloromethane T=20°C;
参考文献
ST. JUDE CHILDREN'S RESEARCH HOSPITAL; FUJII, Naoaki; ACTIS, Marcelo; PUNCHIHEWA, Chandanamali; CONNELLY, Michele; WU, Zhexiang
Patent: WO2013/6734 A1, 2013 ;
Location in patent: Paragraph 00586 ;
反应条件
in methanol; toluene T=20°C;
参考文献
Ocasio, Cory A.; Scanlan, Thomas S.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 2 p. 762 - 770
反应条件
1.1: sodium hydrogencarbonate / water / 0 - 20 °C 1.2: pH Ca. 2 2.1: sodium periodate; acetic acid; potassium iodide; sodium chloride / water / 0 - 20 °C View Scheme
参考文献
Hackenmueller, Sarah A.; Scanlan, Thomas S.
Synthetic Communications, 2013 , vol. 43, # 10 p. 1439 - 1446
反应条件
1.1: thionyl chloride / 0 - 20 °C 2.1: sodium hydrogencarbonate / water / 0 - 20 °C 2.2: pH Ca. 2 3.1: sodium periodate; acetic acid; potassium iodide; sodium chloride / water / 0 - 20 °C View Scheme
参考文献
Hackenmueller, Sarah A.; Scanlan, Thomas S.
Synthetic Communications, 2013 , vol. 43, # 10 p. 1439 - 1446
反应条件
1: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / |Molecular sieve 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C 3: iodine cloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C 4: lithium hydroxide hydrate / water; methanol / 1.5 h / 4 °C 5: hydrogenchloride / 1,4-dioxane / 20 °C / |Inert atmosphere View Scheme
参考文献
Hackenmueller, Sarah A.; Scanlan, Thomas S.
Synthetic Communications, 2013 , vol. 43, # 10 p. 1439 - 1446
反应条件
LiOH*H2O; water in tetrahydrofuran T=20°C; 1 h;
参考文献
Chalker, Justin M.; Wood, Charlotte S. C.; Davis, Benjamin G.
Journal of the American Chemical Society, 2009 , vol. 131, # 45 p. 16346 - 16347
反应条件
1: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / |Molecular sieve 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C 3: lithium hydroxide hydrate / water; methanol / 1.5 h / 4 °C 4: hydrogenchloride / 1,4-dioxane / 20 °C / |Inert atmosphere View Scheme
参考文献
Hackenmueller, Sarah A.; Scanlan, Thomas S.
Synthetic Communications, 2013 , vol. 43, # 10 p. 1439 - 1446
反应条件
1: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / |Molecular sieve 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C 3: lithium hydroxide hydrate / water; methanol / 1.5 h / 4 °C View Scheme
参考文献
Hackenmueller, Sarah A.; Scanlan, Thomas S.
Synthetic Communications, 2013 , vol. 43, # 10 p. 1439 - 1446
