tetrakis(triphenylphosphine) palladium(0); potassium carbonate in tetrahydrofuran; water T=80°C; Suzuki coupling; 24 h; Inert atmosphere;
参考文献
Thompson, Andrew M.; Sutherland, Hamish S.; Palmer, Brian D.; Kmentova, Iveta; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6563 - 6585
1: 5-bromo-thiophene-2-carboxylic acid With sodium carbonate in water T=80°C; 0.75 h; 2: dihydroxy-4-(trifluoromethyl)phenylborane With palladium diacetate in water T=80°C; 114 h; 3: With hydrogenchloride in water T=50°C;
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2005/103039 A1, 2005 ;
Location in patent: Page/Page column 38 ;
WO 2005/103039 A1