[2-[(10R,11S,13S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]2-氨基乙酸酯盐酸盐合成路线 （共 4 条）
→
128887-42-3[2-[(10R,11S,13S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]2-氨基乙酸酯盐酸盐
反应条件
hydrogenchloride in 1,4-dioxane 1 h; Yield given;
参考文献
Ryakhovskaya, M. I.; Popova, E. V.; Grinenko, G. S.; Terekhina, A. I.; Gritsina, G. I.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 3 p. 184 - 189
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 3 p. 26 - 29
→
128887-42-3[2-[(10R,11S,13S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]2-氨基乙酸酯盐酸盐
反应条件
1: 94 percent / pyridine / 0.25 h / 0 °C 2: 93 percent / NaI / acetone / 0.25 h / Heating 3: dimethylformamide / 4 h 4: 3 N HCl / dioxane / 1 h View Scheme
参考文献
Ryakhovskaya, M. I.; Popova, E. V.; Grinenko, G. S.; Terekhina, A. I.; Gritsina, G. I.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 3 p. 184 - 189
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 3 p. 26 - 29
→
128887-42-3[2-[(10R,11S,13S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]2-氨基乙酸酯盐酸盐
反应条件
1: dimethylformamide / 4 h 2: 3 N HCl / dioxane / 1 h View Scheme
参考文献
Ryakhovskaya, M. I.; Popova, E. V.; Grinenko, G. S.; Terekhina, A. I.; Gritsina, G. I.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 3 p. 184 - 189
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 3 p. 26 - 29
→
128887-42-3[2-[(10R,11S,13S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]2-氨基乙酸酯盐酸盐
反应条件
1: 93 percent / NaI / acetone / 0.25 h / Heating 2: dimethylformamide / 4 h 3: 3 N HCl / dioxane / 1 h View Scheme
参考文献
Ryakhovskaya, M. I.; Popova, E. V.; Grinenko, G. S.; Terekhina, A. I.; Gritsina, G. I.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 3 p. 184 - 189
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 3 p. 26 - 29
