AuNTf2(SPhos); water in tetrahydrofuran T=60°C; 24 h;

1: furan With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexane 1 h; Heating; 2: 1-bromo-hexane in tetrahydrofuran; hexane T=20°C; 21.5 h; Further stages.;

1.1: N-chloro-succinimide; L-proline / dichloromethane / 0 - 20 °C / |Inert atmosphere 2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 - 0 °C / |Inert atmosphere 2.2: 0.5 h / -78 °C / |Inert atmosphere 3.1: pyridinium p-toluenesulfonate / water / 12 h / |Reflux; |Inert atmosphere View Scheme

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 - 0 °C / |Inert atmosphere 1.2: 0.5 h / -78 °C / |Inert atmosphere 2.1: pyridinium p-toluenesulfonate / water / 12 h / |Reflux; |Inert atmosphere View Scheme

1: 1) n-BuLi / 1) THF, hexane, 24h, RT, 2) 24h, RT 2: 1) n-BuLi / 1) THF, hexane, 24h, RT, 2) 24h View Scheme

n-butyllithium 1) THF, hexane, 24h, RT, 2) 24h; Yield given. Multistep reaction;