potassium carbonate in N,N-dimethyl-formamide T=80 - 90°C; 6 h;

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 1.2: -78 - 20 °C 2.1: palladium 10 on activated carbon; potassium carbonate / water; acetonitrile / 4 h / 50 - 60 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 - 90 °C View Scheme