(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5R,6R)-4,5-二羟基-6-(羟基甲基)-2-甲氧基四氢吡喃-3-基]氧基-6-甲基四氢吡喃-3,4,5-三醇合成路线 （共 5 条）
→
128962-66-3(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5R,6R)-4,5-二羟基-6-(羟基甲基)-2-甲氧基四氢吡喃-3-基]氧基-6-甲基四氢吡喃-3,4,5-三醇
反应条件
palladium on activated charcoal; hydrogen in methanol Ambient temperature;
参考文献
Ray; Maddali; Roy
Carbohydrate research, 1990 , vol. 197, p. 93 - 100
→
128962-66-3(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5R,6R)-4,5-二羟基-6-(羟基甲基)-2-甲氧基四氢吡喃-3-基]氧基-6-甲基四氢吡喃-3,4,5-三醇
反应条件
1: 95 percent / KOH / dioxane 2: 92 percent / aq. 90percent acetic acid / 2 h / 85 °C 3: 92 percent / H2, 10percent Pd/C / methanol / Ambient temperature View Scheme
参考文献
Ray; Maddali; Roy
Carbohydrate research, 1990 , vol. 197, p. 93 - 100
→
128962-66-3(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5R,6R)-4,5-二羟基-6-(羟基甲基)-2-甲氧基四氢吡喃-3-基]氧基-6-甲基四氢吡喃-3,4,5-三醇
反应条件
1: 92 percent / aq. 90percent acetic acid / 2 h / 85 °C 2: 92 percent / H2, 10percent Pd/C / methanol / Ambient temperature View Scheme
参考文献
Ray; Maddali; Roy
Carbohydrate research, 1990 , vol. 197, p. 93 - 100
→
128962-66-3(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5R,6R)-4,5-二羟基-6-(羟基甲基)-2-甲氧基四氢吡喃-3-基]氧基-6-甲基四氢吡喃-3,4,5-三醇
反应条件
1: 93 percent / toluene-p-sulfonic acid / dimethylformamide / 1.5 h / 70 °C / 12 Torr 2: 72 percent / mercury(II) cyanide, molecular sieve 3 Angstroem / acetonitrile / 24 h / Ambient temperature 3: 95 percent / KOH / dioxane 4: 92 percent / aq. 90percent acetic acid / 2 h / 85 °C 5: 92 percent / H2, 10percent Pd/C / methanol / Ambient temperature View Scheme
参考文献
Ray; Maddali; Roy
Carbohydrate research, 1990 , vol. 197, p. 93 - 100
→
128962-66-3(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5R,6R)-4,5-二羟基-6-(羟基甲基)-2-甲氧基四氢吡喃-3-基]氧基-6-甲基四氢吡喃-3,4,5-三醇
反应条件
1: dibutyltin oxide, tetraethylammonium bromide 2: 93 percent / toluene-p-sulfonic acid / dimethylformamide / 1.5 h / 70 °C / 12 Torr 3: 72 percent / mercury(II) cyanide, molecular sieve 3 Angstroem / acetonitrile / 24 h / Ambient temperature 4: 95 percent / KOH / dioxane 5: 92 percent / aq. 90percent acetic acid / 2 h / 85 °C 6: 92 percent / H2, 10percent Pd/C / methanol / Ambient temperature View Scheme
参考文献
Ray; Maddali; Roy
Carbohydrate research, 1990 , vol. 197, p. 93 - 100
