1.1: lithium chloride; lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere 2.1: dichloromethane / 2 h / Inert atmosphere 3.1: sodium hydroxide / 1,4-dioxane; water / pH 12 / Inert atmosphere 3.2: Inert atmosphere 3.3: Inert atmosphere 4.1: triethylamine / dichloromethane / 0.5 h / Inert atmosphere 5.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / Inert atmosphere 6.1: dichloromethane / 2 h / Inert atmosphere 7.1: water; isopropyl alcohol / 37 °C / pH 7.4 / aq. phosphate buffer View Scheme

1.1: lithium chloride; lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - 20 °C / Inert atmosphere 1.2: 2 h / -78 - 20 °C / Inert atmosphere 2.1: dichloromethane / 2 h / Inert atmosphere 3.1: sodium hydroxide / 1,4-dioxane; water / pH 12 / Inert atmosphere 3.2: Inert atmosphere 3.3: Inert atmosphere 4.1: triethylamine / dichloromethane / 0.5 h / Inert atmosphere 5.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / Inert atmosphere 6.1: dichloromethane / 2 h / Inert atmosphere 7.1: water; isopropyl alcohol / 37 °C / pH 7.4 / aq. phosphate buffer View Scheme