1.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux 1.2: 2 h / -78 °C 1.3: -78 °C 2.1: hydrogenchloride; hydrogen; acetic acid / platinum(IV) oxide / water / 3 h / 20 °C / 760.05 Torr 3.1: sodium hydroxide; water / ethanol / 3 h / 50 °C 3.2: 20 °C 3.3: pH 1 - 2 4.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C 5.1: hydrogen; acetic acid / palladium 10 on activated carbon / ethanol / 20 °C / 760.05 Torr 5.2: pH 10 View Scheme

1.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux 1.2: 2 h / -78 °C 1.3: -78 °C 2.1: hydrogenchloride; hydrogen; acetic acid / platinum(IV) oxide / water / 3 h / 20 °C / 760.05 Torr 3.1: sodium hydroxide; water / ethanol / 3 h / 50 °C 3.2: 20 °C 3.3: pH 1 - 2 4.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C View Scheme

1.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux 1.2: 2 h / -78 °C 1.3: -78 °C 2.1: hydrogenchloride; hydrogen; acetic acid / platinum(IV) oxide / water / 3 h / 20 °C / 760.05 Torr 3.1: sodium hydroxide; water / ethanol / 3 h / 50 °C 4.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C View Scheme

1.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux 1.2: 2 h / -78 °C 1.3: -78 °C 2.1: hydrogenchloride; hydrogen; acetic acid / platinum(IV) oxide / water / 3 h / 20 °C / 760.05 Torr 3.1: sodium hydroxide; water / ethanol / 3 h / 50 °C View Scheme