(2S,2’S)-6-氟-2-(2’-环氧乙烷基)色满合成路线 (共 8 条)
反应条件
1: With sodium hydroxide in water; isopropyl alcohol T=0 - 20°C; Inert atmosphere; 2: With acetic acid in water; isopropyl alcohol; toluene
参考文献
ZACH SYSTEM
Patent: US2011/237808 A1, 2011 ;
Location in patent: Page/Page column 7 ;
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride in dichloromethane T=0 - 4°C; 12 h; 2: With N,N-diisopropyl-1,2-diaminoethane in dichloromethane 0.25 h; Reagent/catalyst; Overall yield = 95 percent; Overall yield = 11 g;
参考文献
Menarini International Operations Luxembourg S.A.; CIPOLLONE, Amalia; D'ANDREA, Piero; FATTORI, Daniela
Patent: WO2013/18053 A1, 2013 ;
Location in patent: Page/Page column 23 ;
反应条件
oxygen; 4-nitro-benzoic acid; Jacobsen's (R,R)-(salen)Co(III) catalyst in tert-butyl methyl ether T=20°C; 1.5 h; Resolution of racemate; Product distribution / selectivity;
参考文献
ZACH SYSTEM S.P.A.
Patent: WO2008/64826 A1, 2008 ;
Location in patent: Page/Page column 24 ;
反应条件
in 1,1-dimethylpropan-1-ol T=20°C; 12 h;
参考文献
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.; MAURO, Sandro; FATTORI, Daniela; D'ANDREA, Piero; CIPOLLONE, Amalia
Patent: WO2012/95707 A1, 2012 ;
Location in patent: Page/Page column 21-22 ;
反应条件
in 1,1-dimethylpropan-1-ol T=20°C; 12 h;
参考文献
Menarini International Operations Luxembourg S.A.; CIPOLLONE, Amalia; D'ANDREA, Piero; FATTORI, Daniela
Patent: WO2013/18053 A1, 2013 ;
Location in patent: Page/Page column 23; 24 ;
反应条件
1.1: sodium hydride / tert-butyl methyl ether; dimethyl sulfoxide / 1 h / 50 °C / |Inert atmosphere 1.2: 1 h / |Inert atmosphere 2.1: 1,1-dimethylpropan-1-ol / 12 h / 20 °C View Scheme
参考文献
Menarini International Operations Luxembourg S.A.; CIPOLLONE, Amalia; D'ANDREA, Piero; FATTORI, Daniela
Patent: WO2013/18053 A1, 2013 ;
参考文献
Menarini International Operations Luxembourg S.A.; CIPOLLONE, Amalia; D'ANDREA, Piero; FATTORI, Daniela
Patent: WO2013/18053 A1, 2013 ;
Location in patent: Page/Page column 24 ;
反应条件
boron trifluoride diethyl etherate in tert-butyl alcohol 4 h; Heating / reflux;
参考文献
ZACH SYSTEM S.P.A.
Patent: WO2008/64826 A1, 2008 ;
Location in patent: Page/Page column 26-27 ;