(2R)-6-氟-2-(2-环氧乙烷基)色满合成路线 （共 5 条）
反应条件
1: With sodium hydroxide in water; isopropyl alcohol T=0 - 20°C; Inert atmosphere; 2: With acetic acid in water; isopropyl alcohol; toluene
参考文献
ZACH SYSTEM
Patent: US2011/237808 A1, 2011 ;
Location in patent: Page/Page column 7 ;
反应条件
4-nitro-benzoic acid; Jacobsen's (R,R)-(salen)Co(III) catalyst in dichloromethane; tert-butyl methyl ether T=20°C; 1 h; Product distribution / selectivity;
参考文献
ZACH SYSTEM S.P.A.
Patent: WO2008/64826 A1, 2008 ;
Location in patent: Page/Page column 25-26 ;
反应条件
1.1: acetic acid / 25 - 95 °C 2.1: pyridine / 20 - 45 °C 3.1: potassium hydroxide / dimethyl sulfoxide / 25 - 45 °C 4.1: methanol / 17 h / Industry scale; Reflux 4.2: Industry scale View Scheme
参考文献
CADILA PHARMACEUTICALS LIMITED; KHAMAR, Bakulesh, Mafatlal; KAGATHARA, Nirav, Keshavlal; MUGALE, Balaji; KORIKANA, Sivaprasad; BAPAT, Uday, Rajaram; MODI, Indravadan, Ambalal
Patent: WO2011/132140 A2, 2011 ;
反应条件
1: isopropyl alcohol / 3 h / Reflux 2: isopropyl alcohol / 23 h / Reflux View Scheme
参考文献
Haldar, Pranab; Golla, China Malakondaiah; Swapna, Akula; Kumar, Karri Vijaya; Jawlekar, Suhas; Tummala, Arjun Kumar; Patro, Deepali; Yarraguntla, Sesha Reddy; Ramakrishnan, Srividya; Chimala, Venkata Ramana Reddy
Patent: US2011/250454 A1, 2011 ;
反应条件
1: ammonia / water; methanol / 6 h / 10 - 35 °C 2: methanol / 12 h / Reflux View Scheme
参考文献
Haldar, Pranab; Golla, China Malakondaiah; Swapna, Akula; Kumar, Karri Vijaya; Jawlekar, Suhas; Tummala, Arjun Kumar; Patro, Deepali; Yarraguntla, Sesha Reddy; Ramakrishnan, Srividya; Chimala, Venkata Ramana Reddy
Patent: US2011/250454 A1, 2011 ;
