N-甲氧基-N-甲基戊酰胺合成路线 （共 7 条）
反应条件
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 20 h;
参考文献
Solvay Pharmaceuticals, B.V.
Patent: US2008/312276 A1, 2008 ;
Location in patent: Page/Page column 9 ;
反应条件
triethylamine in tetrahydrofuran T=20°C; 16 h;
参考文献
Katritzky, Alan R.; Kirichenko, Nataliya; Rogovoy, Boris V.
Synthesis, 2003 , # 18 p. 2777 - 2780
反应条件
in tetrahydrofuran T=22°C;
参考文献
Whipple, Wesley L.; Reich, Hans J.
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2911 - 2912
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane Ambient temperature;
参考文献
Jones Jr.; Schnettler; Huber
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 511 - 518
反应条件
1: tetrahydrofuran / 18 h / 20 °C 2: 65 percent / Et3N / tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
Katritzky, Alan R.; Kirichenko, Nataliya; Rogovoy, Boris V.
Synthesis, 2003 , # 18 p. 2777 - 2780
反应条件
in tetrahydrofuran T=0 - 20°C; 20 h;
参考文献
Solvay Pharmaceuticals, B.V.
Patent: US2008/312276 A1, 2008 ;
Location in patent: Page/Page column 9 ;
反应条件
1: 1) lithium 2,2,6,6-tetramethylpiperidide / 1) THF, -15 to 0 deg C, 20 min, 2) room temperature, 30 min
2: conc. aq. NH4OH, glacial AcOH / 4 h / Heating
View Scheme
参考文献
Flippin, Lee A.; Muchowski, Joseph M.
Journal of Organic Chemistry, 1993 , vol. 58, # 9 p. 2631 - 2632
