trifluoromethyl hypofluorite in various solvent(s) T=-70°C; Yield given;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '906717', constants.ctx, '0')">lithium diisopropyl amide</a> <br />&nbsp;1.) THF, -78 deg C, 0.5 h, 2.) -70 deg C, 30 min;&nbsp;&nbsp;Multistep reaction. Title compound not separated from byproducts;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '906717', constants.ctx, '0')">lithium diisopropyl amide</a> <br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 92 percent / (Me₃Si)2NH / CH₂Cl₂ / Ambient temperature<br />2: 59 percent / tetrahydrofuran / 1.5 h / -78 &deg;C<br />3: 1.) lithium tetramethylpiperidide, 2.) Et₃N / 1) THF, hexane, 0 deg C, 1 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 63 percent / Na, (CH₃)3SiCl / diethyl ether / Heating<br />2: 86 percent / pyridine / 4 &deg;C<br />3: 46 percent / Me₂PhSiLi / tetrahydrofuran / 12 h<br />4: 1.) lithium tetramethylpiperidide, 2.) Et₃N / 1) THF, hexane, 0 deg C, 1 h<br /> <br /> &nbsp;