potassium hydroxide in methanol 4 h; Ambient temperature;

1: AcCl / Heating 2: N-bromosuccinimide (NBS), benzoyl peroxide / CCl4 / 20 h / Heating 3: NaOH, tricaprylmethylammonium chloride / CH2Cl2; H2O / 5 h / Ambient temperature 4: 82 percent / aq. 4 N KOH / methanol / 4 h / Ambient temperature View Scheme

1: N-bromosuccinimide (NBS), benzoyl peroxide / CCl4 / 20 h / Heating 2: NaOH, tricaprylmethylammonium chloride / CH2Cl2; H2O / 5 h / Ambient temperature 3: 82 percent / aq. 4 N KOH / methanol / 4 h / Ambient temperature View Scheme

1: NaOH, tricaprylmethylammonium chloride / CH2Cl2; H2O / 5 h / Ambient temperature 2: 82 percent / aq. 4 N KOH / methanol / 4 h / Ambient temperature View Scheme