1.1: triethylamine; zinc trifluoromethanesulfonate; (1S,2R)-(+)-N-methylephedrine / toluene / 20 °C 1.2: 16 h / 20 °C 2.1: 4-(N,N-dimethlyamino)pyridine; 1H-imidazole / dichloromethane / 20 °C / Inert atmosphere 3.1: ethylene glycol dimethyl ether / 6.5 h / 20 - 65 °C / Inert atmosphere 4.1: potassium carbonate; hydrogen / palladium on activated charcoal / water; methanol / 16 h / 20 °C 5.1: sodium hydroxide / water; methanol / 0.5 h / -5 °C 5.2: 18 h / -5 - 20 °C 5.3: pH 2 - 3 View Scheme