1: ethyl 1-acetyl-1-cyclopropanecarboxylate With bromine in ethanol 2 h; 2: benzylamine in ethanol T=0 - 20°C; Product distribution / selectivity;

1: 1.) N,N'-carbonyldiimidazole, 2.) MgCl2 / 1.) THF, RT, 2 h, 2.) THF, a) 50 deg C, 6 h, b) RT, 16 h 2: 72 percent / K2CO3 / acetone / 6 h / Heating 3: trifluoroacetic acid / CH2Cl2 / 1.5 h / Ambient temperature 4: toluene / 0.5 h / Heating View Scheme

1: 72 percent / K2CO3 / acetone / 6 h / Heating 2: trifluoroacetic acid / CH2Cl2 / 1.5 h / Ambient temperature 3: toluene / 0.5 h / Heating View Scheme

1: trifluoroacetic acid / CH2Cl2 / 1.5 h / Ambient temperature 2: toluene / 0.5 h / Heating View Scheme

in toluene 0.5 h; Heating; Yield given;

1: 65 percent / 0.1percent aq. K2HPO4/KH2PO4 buffer pH=6.0 / 240 h / 30 °C / Phaeocreopsis sp. JSM 1880 2: 1.) Ph3P, diethylazodicarboxylate, diphenylphosphoryl azide, 2.) LiAlH4 / 1.) THF, RT, 24 h, 2.) THF, reflux, 1 h View Scheme

1: 65 percent / 0.1percent aq. K2HPO4/KH2PO4 buffer pH=6.0 / 240 h / 30 °C / Phaeocreopsis sp. JSM 1880 2: 1.) Ph3P, diethylazodicarboxylate, diphenylphosphoryl azide, 2.) LiAlH4 / 1.) THF, RT, 24 h, 2.) THF, reflux, 1 h 3: 92 percent / toluene / 18 h / Ambient temperature 4: 90 percent / H2 / 5percent Pd/C / ethanol / 5 h / 60 °C / 15200 - 19000 Torr View Scheme