2',4',5'-三氟苯乙酮合成路线 （共 8 条）
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; ethanol; acetic acid
参考文献
Bayer Aktiengesellschaft
Patent: US5142092 A1, 1992 ;
反应条件
aluminium trichloride T=80°C; Acylation; 24 h;
参考文献
Braish, Tamim F.; Fox, Darrell E.
Organic Preparations and Procedures International, 1991 , vol. 23, # 5 p. 655 - 658
反应条件
sodium hypochlorite Oxidation; 6 h; Heating;
参考文献
Braish, Tamim F.; Fox, Darrell E.
Organic Preparations and Procedures International, 1991 , vol. 23, # 5 p. 655 - 658
反应条件
bromine in dichloromethane T=23°C; 2 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2008/63287 A2, 2008 ;
Location in patent: Page/Page column 109 ;
反应条件
1: 94 percent / sodium hydroxide, sodium hypochlorite / H2O / 22 h / below 25 deg C 2: thionyl chloride / 4 h / 80 °C View Scheme
参考文献
Chu, Daniel T. W.; Nordeen, Carl W.; Hardy, Dwight J.; Swanson, Robert N.; Giardina, William J.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 168 - 174
反应条件
sodium hydride T=20°C;
参考文献
Chepyala, Naveenkumar R.; Durgi, Rajashaker R.; Tatini, Lakshmi K.; Subbaraju, Gottumukkala V.; Hindupur, Rama M.; Dhanvada, Muralimohan R.
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 637 - 643
反应条件
1: 94 percent / sodium hydroxide, sodium hypochlorite / H2O / 22 h / below 25 deg C 2: thionyl chloride / 4 h / 80 °C 3: 1.) biquinoline, n-butyllithium / 1.) THF, -30 deg C to - 5 deg C, 2.) -50 deg C, 0.5 h View Scheme
参考文献
Chu, Daniel T. W.; Nordeen, Carl W.; Hardy, Dwight J.; Swanson, Robert N.; Giardina, William J.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 168 - 174
反应条件
1: 94 percent / sodium hydroxide, sodium hypochlorite / H2O / 22 h / below 25 deg C
2: thionyl chloride / 4 h / 80 °C
3: 1.) biquinoline, n-butyllithium / 1.) THF, -30 deg C to - 5 deg C, 2.) -50 deg C, 0.5 h
4: 1.) acetic anhydride / 1.) 125 deg C, 2 h, 2.) methylene chloride, 45 min
5: 77 percent / sodium hydride / tetrahydrofuran / 13 h / 50 °C
6: 98 percent / 6 N hydrochloric acid / trifluoroacetic acid / 48 h / 70 °C
View Scheme
参考文献
Chu, Daniel T. W.; Nordeen, Carl W.; Hardy, Dwight J.; Swanson, Robert N.; Giardina, William J.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 168 - 174
