5-氟-2-(嘧啶-2-基)苯甲酸甲酯合成路线 （共 2 条）
反应条件
sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 2-methyl tetrahydrofuran; water T=74°C;
参考文献
JANSSEN PHARMACEUTICA NV; LETAVIC, Michael; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHIREMAN, Brock, T.; SWANSON, Devin
Patent: WO2012/145581 A1, 2012 ;
Location in patent: Page/Page column 51-52 ;
WO 2012/145581 A1
反应条件
1: sulfuric acid / 15 h / 65 °C 2: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / tetrahydrofuran / 1 h / 65 °C / Inert atmosphere 3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / water; 2-methyl tetrahydrofuran / 74 °C View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; BRANSTETTER, Bryan, James; LETAVIC, Michael, A.; LY, Kiev, S.; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T.
Patent: WO2011/50202 A1, 2011 ;
WO 2011/050202 A1
