1: With sodium hydroxide in water; acetone T=20°C; 2: With acetic acid in water; acetone T=12°C; pH=8 - 9; 1 h;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 6 h / Reflux<br />1.2: 20 &deg;C<br />2.1: sodium hydroxide / dichloromethane; water / 6.75 h / 16 - 20 &deg;C / Reflux<br />3.1: hydrogen bromide / methanol / 5 - 58 &deg;C / pH 1<br />4.1: boron trichloride / dichloromethane / 2.5 h / 37 - 39 &deg;C<br />4.2: 0.75 h / 17 - 32 &deg;C / Reflux<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587158', constants.ctx, '0')">hydrogen bromide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=1 - 35&deg;C;&nbsp;pH=1.5;&nbsp;&nbsp;Reflux;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 8 steps<br /> </b>1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / ethyl acetate; water / 13 - 35 &deg;C / Reflux<br />2.1: formic acid; sulfuric acid / acetic acid<br />3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 5 h / 65 - 70 &deg;C<br />4.1: iron(III) sulfate pentahydrate; iron / toluene / 99 - 114 &deg;C<br />4.2: 62 - 66 &deg;C / Inert atmosphere<br />5.1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 6 h / Reflux<br />5.2: 20 &deg;C<br />6.1: sodium hydroxide / dichloromethane; water / 6.75 h / 16 - 20 &deg;C / Reflux<br />7.1: hydrogen bromide / methanol / 5 - 58 &deg;C / pH 1<br />8.1: boron trichloride / dichloromethane / 2.5 h / 37 - 39 &deg;C<br />8.2: 0.75 h / 17 - 32 &deg;C / Reflux<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: sodium hydroxide / dichloromethane; water / 6.75 h / 16 - 20 &deg;C / Reflux<br />2.1: hydrogen bromide / methanol / 5 - 58 &deg;C / pH 1<br />3.1: boron trichloride / dichloromethane / 2.5 h / 37 - 39 &deg;C<br />3.2: 0.75 h / 17 - 32 &deg;C / Reflux<br /> <br /> &nbsp;