potassium hydroxide in ethanol Ambient temperature;

1: 1) n-butyllithium / 1) THF, -41 deg C, 15 min, 2a) -41 deg C, 1 h, 2b) r.t, 1 h 2: 58.9 percent / triethylamine / methanol / Ambient temperature 3: 50 percent / aq. KOH / aq. ethanol / Ambient temperature View Scheme

1: 1) n-butyllithium / 1) THF, -41 deg C, 15 min, 2a) -41 deg C, 1 h, 2b) r.t, 1 h 2: 58.9 percent / triethylamine / methanol / Ambient temperature 3: 50 percent / aq. KOH / aq. ethanol / Ambient temperature View Scheme

1: 58.9 percent / triethylamine / methanol / Ambient temperature 2: 50 percent / aq. KOH / aq. ethanol / Ambient temperature View Scheme