2,3-二氢-1,4-二噁英并[2,3-B]嘧啶合成路线 （共 9 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20 - 90°C;
参考文献
KOWA COMPANY, LTD.
Patent: US2010/280013 A1, 2010 ;
Location in patent: Page/Page column 49 ;
反应条件
lithium hydride in dimethyl sulfoxide T=110°C; 1.5 h;
参考文献
Deshmukh, Mahesh S.; Das, Biswajit; Jain, Nidhi
RSC Advances, 2013 , vol. 3, # 44 p. 22389 - 22396
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran 2 h; Ambient temperature;
参考文献
Joseph, Benoit; Benarab, Abdelhakim; Guillaumet, Gerald
Heterocycles, 1994 , vol. 38, # 6 p. 1355 - 1360
反应条件
1: 98 percent / K2CO3 / acetone / 16 h 2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 100 deg C, 3 d 3: 98 percent / H2 / 10percent Pd/C / methanol / 16 h / 2327.2 Torr 4: 76 percent / DIAD, PPh3 / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 38, # 6 p. 1355 - 1360
反应条件
1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 100 deg C, 3 d 2: 98 percent / H2 / 10percent Pd/C / methanol / 16 h / 2327.2 Torr 3: 76 percent / DIAD, PPh3 / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 38, # 6 p. 1355 - 1360
反应条件
1: 98 percent / H2 / 10percent Pd/C / methanol / 16 h / 2327.2 Torr 2: 76 percent / DIAD, PPh3 / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 38, # 6 p. 1355 - 1360
反应条件
sodium hydride 1.) HMPTA, 2.) 18 h; Yield given. Multistep reaction;
参考文献
Chemische Berichte, , vol. 123, # 12 p. 2453 - 2454
反应条件
n-butyllithium; 1,2,2-trichloro-1,1,2-trichloro-ethane 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 10 min; Yield given. Multistep reaction;
参考文献
Joseph, Benoit; Benarab, Abdelhakim; Guillaumet, Gerald
Heterocycles, 1994 , vol. 38, # 6 p. 1355 - 1360
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C; 0.75 h;
2: With 1,2-dibromo-1,1,2,2-tetrafluoroethane in tetrahydrofuran
0.583333 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/2992 A1, 2004 ;
Location in patent: Page 47 ;
