hydrogen; palladium on activated charcoal in ethyl acetate

tetrabutyl ammonium fluoride in tetrahydrofuran 2 h; Ambient temperature;

1: 93 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature 2: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2.) THF, hexane, from -70 deg C to RT, 2.5 h 3: 100 percent / DMSO, oxalyl chloride / CH2Cl2 / 0.25 h / -55 - -50 °C 4: 91 percent / diethyl ether / 1 h / Ambient temperature 5: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 6: 76 percent / H2 / 30percent Pd/C / ethyl acetate View Scheme

1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2.) THF, hexane, from -70 deg C to RT, 2.5 h 2: 100 percent / DMSO, oxalyl chloride / CH2Cl2 / 0.25 h / -55 - -50 °C 3: 91 percent / diethyl ether / 1 h / Ambient temperature 4: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 5: 76 percent / H2 / 30percent Pd/C / ethyl acetate View Scheme

1: 91 percent / diethyl ether / 1 h / Ambient temperature 2: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 3: 76 percent / H2 / 30percent Pd/C / ethyl acetate View Scheme

1: 100 percent / DMSO, oxalyl chloride / CH2Cl2 / 0.25 h / -55 - -50 °C 2: 91 percent / diethyl ether / 1 h / Ambient temperature 3: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 4: 76 percent / H2 / 30percent Pd/C / ethyl acetate View Scheme

1: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 2: 76 percent / H2 / 30percent Pd/C / ethyl acetate View Scheme

暂无反应条件数据

1: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 2.) ether, hexane, from -70 deg C to RT 2: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 3: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme

1: 1.) NaH / 1.) THF, 2.) THF, RT, 2 h 2: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature View Scheme