(4R)-4-羟基-1-三苯甲基-L-脯氨酸甲酯合成路线 （共 15 条）
反应条件
1: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 2: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 4: TFA / CH2Cl2 View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 2: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 4: TFA / CH2Cl2 5: Et3N / methanol View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 2: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 4: TFA / CH2Cl2 View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 2: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
formic acid in 1,2-dichloro-ethane
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
