3-[2-羟基-3-(2-硝基咪唑-1-基)丙基]-1,3-恶唑烷-2-酮合成路线 （共 4 条）
反应条件
caesium carbonate in ethanol T=85°C; 4 h;
参考文献
Sercel, Anthony D.; Beylin, Vladimir G.; Marlatt, Mark E.; Leja, Boguslawa; Showalter, H. D. Hollis; Michel, Andre
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1597 - 1604
反应条件
phosphate-buffered saline (PBS, Oxoid) in water T=23°C; other <(haloethyl)amino>propyl-2-nitroimidazoles; pH 7.0 - 7.5; Product distribution;
参考文献
Jenkins, Terence C.; Naylor, Matthew A.; O'Neill, Peter; Threadgill, Michael D.; Cole, Shirley; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2603 - 2610
反应条件
hydrogen bromide; acetic acid 20.3 h; Ambient temperature;
参考文献
Suto, Mark J.; Stier, Michael A.; Werbel, Leslie M.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1207 - 1209
反应条件
1: 54 percent / 31percent HBr, HOAc / 20.3 h / Ambient temperature
2: Et3N / various solvent(s) / 0.5 h / 25 °C
View Scheme
参考文献
Suto, Mark J.; Stier, Michael A.; Werbel, Leslie M.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1207 - 1209
