1.1: sodium hydrogencarbonate / ethyl acetate 1.2: 20 °C 1.3: 80 °C / Inert atmosphere 2.1: dichloro bis(acetonitrile) palladium(II) / acetonitrile / 20 - 80 °C / Inert atmosphere View Scheme

1.1: sodium hydrogencarbonate / ethyl acetate 1.2: 20 °C 1.3: 80 °C / Inert atmosphere 2.1: dichloro bis(acetonitrile) palladium(II) / acetonitrile / 20 - 80 °C / Inert atmosphere 3.1: triethylamine / dichloromethane / 0 - 20 °C 4.1: hydrogen / 5 palladium on charcoal / tetrahydrofuran / 96 h / 50 °C / 2250.23 - 3000.3 Torr / autoclave; Inert atmosphere View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: ammonium chloride; zinc / water; ethanol / 4 h / 85 &deg;C<br />2: dichloromethane / 16 h / 20 &deg;C<br /> <br /> &nbsp;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '26548192', constants.ctx, '0')">C₁₆H₁₆BrFN₂O₄</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1740761', constants.ctx, '0')">Isopropyl acetate</a> <br />T=30&deg;C;&nbsp;P=750.075&nbsp;Torr;&nbsp;&nbsp;Inert atmosphereMolecular sieve;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '472690', constants.ctx, '0')">toluene-4-sulfonic acid</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br /> <br /> <br /> &nbsp;

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=20&deg;C;&nbsp;16&nbsp;h;&nbsp;<br /> <br /> &nbsp;