3-[(1R)-3-二异丙基氨基-1-苯基丙基-4-羟基苯甲酸甲酯二苯甲酰-D-酒石酸盐合成路线 （共 5 条）
反应条件
in ethanol T=20 - 60°C; Inert atmosphere;
参考文献
DIPHARMA FRANCIS S.R.L.
Patent: US2011/152367 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
1: methanesulfonic acid / water / 50 - 55 °C / Inert atmosphere 2: ethanol / 60 °C / Inert atmosphere View Scheme
参考文献
Dipharma Francis S.r.l.
Patent: EP2338871 A1, 2011 ;
反应条件
1: methanesulfonic acid / water / 50 - 55 °C / Inert atmosphere 2: ethanol / 60 °C / Inert atmosphere View Scheme
参考文献
Dipharma Francis S.r.l.
Patent: EP2338871 A1, 2011 ;
反应条件
1: With sodium hydrogencarbonate in ethyl acetate Inert atmosphere; 2: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 3.5 h; 3: With ammonium chloride in tetrahydrofuran T=-10 - 20°C; 0.5 h;
参考文献
DIPHARMA FRANCIS S.r.I.
Patent: US2011/105783 A1, 2011 ;
Location in patent: Page/Page column 6 ;
反应条件
1.1: sodium hydrogencarbonate / ethyl acetate / Inert atmosphere 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 20 °C 2.2: -10 °C 3.1: sodium hydroxide / toluene; water / 0.17 h / 20 °C / Inert atmosphere View Scheme
