甲基2,3-二脱氧-3-氟-5-O-(4-苯基苯甲酰基)-α-D-赤型-呋喃戊糖苷合成路线 （共 3 条）
反应条件
1: 89 percent / TMS-OTf / acetonitrile / 1) 1.5h, -30 deg C 2) 2.5h, r.t. 2: 50 percent / NH3 / methanol / 24 h / Ambient temperature View Scheme
参考文献
Motawia, Mohammed S.; Pedersen, Erik B.
Liebigs Annalen der Chemie, 1990 , # 11 p. 1137 - 1139
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile 1) 1.5h, -30 deg C 2) 2.5h, r.t.;
参考文献
Motawia, Mohammed S.; Pedersen, Erik B.
Liebigs Annalen der Chemie, 1990 , # 11 p. 1137 - 1139
反应条件
1.1: H2SO4 / acetic acid / 2.5 h / 0 °C
2.1: aq. HCl / toluene; dioxane; cyclohexane / 8 h / 0 °C
3.1: o-H3PO4; nBu3N; 4 Angstroem molecular sieve / acetonitrile; various solvent(s) / 6 h / 0 °C
3.2: acetonitrile; various solvent(s)
4.1: KOH / H2O / 48 h / 50 °C
5.1: PNPase; CaCl2 / H2O / 5 h / 40 - 60 °C / Enzymatic reaction
View Scheme
参考文献
Komatsu, Hironori; Araki, Tadashi
Tetrahedron Letters, 2003 , vol. 44, # 14 p. 2899 - 2901
