4-(2-甲氧基苯基)-2-[(5-甲基-1H-咪唑-4-基)甲基]-1,3-噻唑合成路线 （共 6 条）
反应条件
in isopropyl alcohol T=80°C; 3 h;
参考文献
Rosen, Terry; Nagel, Arthur A.; Rizzi, James P.; Ives, Jeffrey L.; Daffeh, June B.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2715 - 2720
反应条件
hydrogen; triethylamine; palladium on activated charcoal in tetrahydrofuran 5 h;
参考文献
Rosen; Seeger; McLean; Nagel; Ives; Guarino; Bryce; Furman; Roth; Chalabi; Windels
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3020 - 3023
反应条件
1: 3.4 g / N-bromosuccinimide / methanol / Ambient temperature 2: 2.) 10percent Pd/C / 1.) 2-propanol, 80 deg C, 1.5 h, 2.) CHCl3, 30 min 3: H2, Et3N / 10percent Pd/C / tetrahydrofuran / 5 h View Scheme
参考文献
Rosen; Seeger; McLean; Nagel; Ives; Guarino; Bryce; Furman; Roth; Chalabi; Windels
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3020 - 3023
反应条件
1: 82 percent / HCl(gas) / ethyl acetate / 5.5 h / Ambient temperature 2: 2.) 10percent Pd/C / 1.) 2-propanol, 80 deg C, 1.5 h, 2.) CHCl3, 30 min 3: H2, Et3N / 10percent Pd/C / tetrahydrofuran / 5 h View Scheme
参考文献
Rosen; Seeger; McLean; Nagel; Ives; Guarino; Bryce; Furman; Roth; Chalabi; Windels
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3020 - 3023
反应条件
1: 2.) 10percent Pd/C / 1.) 2-propanol, 80 deg C, 1.5 h, 2.) CHCl3, 30 min 2: H2, Et3N / 10percent Pd/C / tetrahydrofuran / 5 h View Scheme
参考文献
Rosen; Seeger; McLean; Nagel; Ives; Guarino; Bryce; Furman; Roth; Chalabi; Windels
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3020 - 3023
反应条件
1: 2.) 10percent Pd/C / 1.) 2-propanol, 80 deg C, 1.5 h, 2.) CHCl3, 30 min 2: H2, Et3N / 10percent Pd/C / tetrahydrofuran / 5 h View Scheme
参考文献
Rosen; Seeger; McLean; Nagel; Ives; Guarino; Bryce; Furman; Roth; Chalabi; Windels
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3020 - 3023
