hydrogenchloride in ethyl acetate T=80°C; 1 h;

<b>Multi-step reaction with 3 steps<br /> </b>1: 74 percent / tetrahydrofuran / 1 h / 70 &deg;C<br />2: 75 percent / 5 N NaOH / methanol / 1 h / 100 &deg;C<br />3: 65 percent / diphenyl phosphorazidate (DPPA), NEt₃ / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 20 deg C, 12 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 75 percent / 5 N NaOH / methanol / 1 h / 100 &deg;C<br />2: 65 percent / diphenyl phosphorazidate (DPPA), NEt₃ / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 20 deg C, 12 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 69 percent / ethanol; H₂O / 5 h / 80 &deg;C<br />2: 74 percent / tetrahydrofuran / 1 h / 70 &deg;C<br />3: 75 percent / 5 N NaOH / methanol / 1 h / 100 &deg;C<br />4: 65 percent / diphenyl phosphorazidate (DPPA), NEt₃ / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 20 deg C, 12 h<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '2058967', constants.ctx, '0')">diphenyl phosphoryl azide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />&nbsp;1.) 0 deg C, 1 h, 2.) 20 deg C, 12 h;&nbsp;<br /> &nbsp;