7-氯咪唑并[1,2-a]吡啶-3-羧酸乙酯合成路线 （共 3 条）
反应条件
1: potassium (1E)-2-chloro-3-ethoxy-3-oxoprop-1-en-1-olate With hydrogenchloride in ethanol; water 0.25 h; 2: 2-amino-4-chloro-pyridine in ethanol; water T=70°C; 19 h; 3: With sodium carbonate in ethanol; water T=20°C; pH=11;
参考文献
ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; DELISLE, Robert Kirk; HICKEN, Erik James; KENNEDY, April L.; MARESKA, David A.; MARMSATER, Fredrik P.; MUNSON, Mark C.; NEWHOUSE, Brad; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian
Patent: WO2012/82689 A1, 2012 ;
Location in patent: Page/Page column 63-64; 77-78 ;
WO 2012/082689 A1
参考文献
FENG, Yangbo; CHEN, Yen Ting; SESSIONS, Hampton; MISHRA, Jitendra K.; CHOWDHURY, Sarwat; YIN, Yan; LOGRASSO, Philip; LUO, Jun-Li; BANNISTER, Thomas; SCHROETER, Thomas
Patent: WO2011/50245 A1, 2011 ;
Location in patent: Page/Page column 111 ;
WO 2011/050245 A1
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=60°C; 2: With hydrogenchloride in water pH=4;
参考文献
FENG, Yangbo; CHEN, Yen Ting; SESSIONS, Hampton; MISHRA, Jitendra K.; CHOWDHURY, Sarwat; YIN, Yan; LOGRASSO, Philip; LUO, Jun-Li; BANNISTER, Thomas; SCHROETER, Thomas
Patent: WO2011/50245 A1, 2011 ;
Location in patent: Page/Page column 112 ;
WO 2011/050245 A1
