2-氧代-2H-吡喃-5-甲腈合成路线 （共 7 条）
反应条件
amidosulfamic acid 1a) 120 deg C, 1b) 119-120 deg C, 3h;
参考文献
Kvita; Sauter
Helvetica Chimica Acta, 1990 , vol. 73, # 4 p. 883 - 889
反应条件
1: thionyl chloride / 1 h / |Inert atmosphere; |Reflux 2: amidosulfamic acid / 1 h / 120 °C View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
反应条件
1: T=-263.16°C; 2 h; UV-irradiation; 2: T=-263.16°C; 0.5 h; UV-irradiation;
参考文献
Menke, Jessica L.; McMahon, Robert J.
Canadian Journal of Chemistry, 2011 , vol. 89, # 2 p. 186 - 194
反应条件
1: 2-Oxo-2H-pyran-5-carboxylic acid With thionyl chloride
1 h;
2: 2-oxo-2H-pyran-5-carbonyl chloride With amidosulfamic acid
T=120°C; 1 h;
3: δ-cyano-α-pyrone With ethylene glycol dimethyl ether; pyridinium tribromide in toluene
4 h; Inert atmsphere;
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
pyridinium bromide perbromide in ethylene glycol dimethyl ether; toluene
4 h; Inert atmosphereReflux;
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
反应条件
1: pyridinium bromide perbromide / ethylene glycol dimethyl ether; toluene / 4 h / |Inert atmosphere; |Reflux
2: isopentyl nitrite; trifluoroacetic acid / ethylene glycol dimethyl ether / 0.5 h / |Reflux
View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
反应条件
1.1: pyridinium bromide perbromide / ethylene glycol dimethyl ether; toluene / 4 h / |Inert atmosphere; |Reflux
2.1: isopentyl nitrite; trifluoroacetic acid / ethylene glycol dimethyl ether / 0.5 h / |Reflux
3.1: hexane; tetrahydrofuran / 0.5 h / -75 °C / |Inert atmosphere
3.2: -75 - -60 °C
View Scheme
参考文献
Ashworth; Bowden; Dembofsky; Levin; Moss; Robinson; Szczur; Virica
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 74 - 81
