吡格列酮噻唑烷二酮开环-beta-D-葡糖苷酸合成路线 （共 5 条）
反应条件
1: water; acetonitrile 2: sodium acetate / water; acetonitrile / 296 h / 20 °C View Scheme
参考文献
Uchiyama, Minoru; Fischer, Thomas; Mueller, Juergen; Oguchi, Minoru; Yamamura, Naotoshi; Koda, Hiroko; Iwabuchi, Haruo; Izumi, Takashi
Drug Metabolism and Disposition, 2010 , vol. 38, # 6 p. 946 - 956
反应条件
1: hydrogenchloride / 1,4-dioxane / 76 h / 20 °C 2: morpholine; tetrakis(triphenylphosphine) palladium(0) / dichloromethane / 4 h / 20 °C 3: water; acetonitrile 4: sodium acetate / water; acetonitrile / 296 h / 20 °C View Scheme
参考文献
Uchiyama, Minoru; Fischer, Thomas; Mueller, Juergen; Oguchi, Minoru; Yamamura, Naotoshi; Koda, Hiroko; Iwabuchi, Haruo; Izumi, Takashi
Drug Metabolism and Disposition, 2010 , vol. 38, # 6 p. 946 - 956
反应条件
1: morpholine; tetrakis(triphenylphosphine) palladium(0) / dichloromethane / 4 h / 20 °C 2: water; acetonitrile 3: sodium acetate / water; acetonitrile / 296 h / 20 °C View Scheme
参考文献
Uchiyama, Minoru; Fischer, Thomas; Mueller, Juergen; Oguchi, Minoru; Yamamura, Naotoshi; Koda, Hiroko; Iwabuchi, Haruo; Izumi, Takashi
Drug Metabolism and Disposition, 2010 , vol. 38, # 6 p. 946 - 956
反应条件
1: caesium carbonate / acetonitrile / 3 h / 70 °C 2: hydrogenchloride / 1,4-dioxane / 76 h / 20 °C 3: morpholine; tetrakis(triphenylphosphine) palladium(0) / dichloromethane / 4 h / 20 °C 4: water; acetonitrile 5: sodium acetate / water; acetonitrile / 296 h / 20 °C View Scheme
参考文献
Uchiyama, Minoru; Fischer, Thomas; Mueller, Juergen; Oguchi, Minoru; Yamamura, Naotoshi; Koda, Hiroko; Iwabuchi, Haruo; Izumi, Takashi
Drug Metabolism and Disposition, 2010 , vol. 38, # 6 p. 946 - 956
反应条件
1: caesium carbonate / acetonitrile / 3 h / 70 °C 2: hydrogenchloride / 1,4-dioxane / 76 h / 20 °C 3: morpholine; tetrakis(triphenylphosphine) palladium(0) / dichloromethane / 4 h / 20 °C 4: water; acetonitrile 5: sodium acetate / water; acetonitrile / 296 h / 20 °C View Scheme
参考文献
Uchiyama, Minoru; Fischer, Thomas; Mueller, Juergen; Oguchi, Minoru; Yamamura, Naotoshi; Koda, Hiroko; Iwabuchi, Haruo; Izumi, Takashi
Drug Metabolism and Disposition, 2010 , vol. 38, # 6 p. 946 - 956
