1: acetophenone With polymer bound piperazine; toluene-4-sulfonic acid in benzene 24 h; Heating; 2: 4-trifluoromethylbenzoyl chloride With triethylamine in dichloromethane 3: With hydrogenchloride; water in tetrahydrofuran T=20°C; 0.333333 h;

methylene bis(iodozinc) in tetrahydrofuran T=25°C; Grob type fragmentation; Inert atmosphere;

sodium hydride in tetrahydrofuran Heating;

sodium hydride in tetrahydrofuran; mineral oil 16.3333 h; Inert atmosphereReflux;