反应条件
1.1: sodium hydroxide / methanol / 4 h / 50 °C 2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C 3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 °C 3.2: 3 h / 5 - 20 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; MAYNARD, Andy; MILLER, John; PATTERSON, Dan; PEAT, Andrew, James; POWERS, Jeremiah; PRICE, Daniel, J.; ROBERTS, Chris; TAI, Vincent; YOUNGMAN, Michael
Patent: WO2011/50284 A1, 2011 ;