1: 1.) dimethyldibromohydantoin, 2.) K2CO3 / 1.) H2O, acetone, 0 deg C, 2.) MeOH 2: 84 percent / NaN3, NH4Cl / ethanol; H2O / 90 °C 3: diethylaminosulphur trifluoride (DAST) / CH2Cl2 / 0 °C 4: H2 / Lindlar catalyst / ethanol 5: Et3N / CH2Cl2 / Ambient temperature 6: H2 / Raney Ni / dioxane 7: H+ 8: NH3(l) / 18 h / Ambient temperature 9: aq. HCl / 0.08 h View Scheme

1: 84 percent / NaN3, NH4Cl / ethanol; H2O / 90 °C 2: diethylaminosulphur trifluoride (DAST) / CH2Cl2 / 0 °C 3: H2 / Lindlar catalyst / ethanol 4: Et3N / CH2Cl2 / Ambient temperature 5: H2 / Raney Ni / dioxane 6: H+ 7: NH3(l) / 18 h / Ambient temperature 8: aq. HCl / 0.08 h View Scheme

1: Et3N / CH2Cl2 / Ambient temperature 2: H2 / Raney Ni / dioxane 3: H+ 4: NH3(l) / 18 h / Ambient temperature 5: aq. HCl / 0.08 h View Scheme

1: H2 / Raney Ni / dioxane 2: H+ 3: NH3(l) / 18 h / Ambient temperature 4: aq. HCl / 0.08 h View Scheme