N-4-Cbz-哌嗪-2-甲酸甲酯合成路线 （共 4 条）
反应条件
in sodium hydrogencarbonate
反应条件
2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate in isopropanol acetate T=23°C; 24 h; Resolution of racemate;
参考文献
Hsieh, Sheng-Ying; Binanzer, Michael; Kreituss, Imants; Bode, Jeffrey W.
Chemical Communications, 2012 , vol. 48, # 71 p. 8892 - 8894
反应条件
triethylamine in dichloromethane; water
参考文献
Abbott Laboratories
Patent: US2004/116518 A1, 2004 ;
Location in patent: Page 42 ;
反应条件
2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate in isopropanol acetate
T=23°C; 24 h; Resolution of racemate;
参考文献
Hsieh, Sheng-Ying; Binanzer, Michael; Kreituss, Imants; Bode, Jeffrey W.
Chemical Communications, 2012 , vol. 48, # 71 p. 8892 - 8894
