1: dichloromethane / 0 - 20 °C 2: sodium hydroxide / water / 4 h / 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / 1,4-dioxane; water / 16 h / 20 °C View Scheme
参考文献
Jadhav, Gopal P.; Chhabra, Siri Ram; Telford, Gary; Hooi, Doreen S. W.; Righetti, Karima; Williams, Paul; Kellam, Barrie; Pritchard, David I.; Fischer, Peter M.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3348 - 3359
1: sodium hydroxide / water / 4 h / 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / 1,4-dioxane; water / 16 h / 20 °C View Scheme
参考文献
Jadhav, Gopal P.; Chhabra, Siri Ram; Telford, Gary; Hooi, Doreen S. W.; Righetti, Karima; Williams, Paul; Kellam, Barrie; Pritchard, David I.; Fischer, Peter M.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3348 - 3359
