(3-氟-2-甲基苯基)-氨基甲酸叔丁酯合成路线 （共 4 条）
反应条件
in tetrahydrofuran 16 h; Heating / reflux;
参考文献
Wyeth
Patent: US2008/51585 A1, 2008 ;
Location in patent: Page/Page column 18 ;
反应条件
1: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 5 min 2: 12N HCl / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: 1) s-BuLi / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 1 min 2: 10percent HCl / ethanol / 0.25 h / Heating View Scheme
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
sec.-butyllithium
1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 1 min; Multistep reaction;
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
