4-氟-1H-吲哚-1-羧酸叔丁酯合成路线 （共 8 条）
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 4 h;
参考文献
SANOFI-AVENTIS
Patent: WO2008/14186 A1, 2008 ;
Location in patent: Page/Page column 45-46 ;
WO 2008/014186 A1
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; t-Bu Brett Phos; cesium fluoride in toluene T=110°C; 12 h;
参考文献
Watson, Donald A.; Su, Mingjuan; Teverovskiy, Georgiy; Zhang, Yong; Garcia-Fortanet, Jorge; Kinzel, Tom; Buchwaldf, Stephen L.
Science, 2009 , vol. 325, # 5948 p. 1661 - 1664
参考文献
Bayer HealthCare AG
Patent: US2007/185121 A1, 2007 ;
反应条件
hydrogenchloride in tetrahydrofuran Ambient temperature; Yield given;
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: tetrahydrofuran / Heating 2: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 5 min 3: 12N HCl / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: tetrahydrofuran / Heating 2: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 5 min 3: 12N HCl / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 5 min 2: 12N HCl / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: With tri-isopropoxy-borane; lithium diisopropyl amide in tetrahydrofuran T=0°C; 1.5 h; 2: With hydrogenchloride; water in tetrahydrofuran
参考文献
SANOFI-AVENTIS
Patent: WO2008/14186 A1, 2008 ;
Location in patent: Page/Page column 46 ;
WO 2008/014186 A1
