N-(boc)-4-氯吲哚合成路线 （共 9 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C;
参考文献
Liu, Qiang; Zhao, Qing Yong; Liu, Jie; Wu, Pan; Yi, Hong; Lei, Aiwen
Chemical Communications, 2012 , vol. 48, # 26 p. 3239 - 3241
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate in toluene T=110°C; 16 h; Inert atmosphere;
参考文献
Henderson, Luke C.; Lindon, Matthew J.; Willis, Michael C.
Tetrahedron, 2010 , vol. 66, # 33 p. 6632 - 6638
反应条件
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine in toluene T=110°C; 16 h; Inert atmosphere;
参考文献
Henderson, Luke C.; Lindon, Matthew J.; Willis, Michael C.
Tetrahedron, 2010 , vol. 66, # 33 p. 6632 - 6638
反应条件
hydrogenchloride in tetrahydrofuran Ambient temperature; Yield given;
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: tetrahydrofuran / Heating 2: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 5 min 3: 12N HCl / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: tetrahydrofuran / Heating 2: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 5 min 3: 12N HCl / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 5 min 2: 12N HCl / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Clark; Muchowski; Fisher; Flippin; Repke; Souchet
Synthesis, 1991 , # 10 p. 871 - 878
反应条件
1: With tri-isopropoxy-borane; lithium diisopropyl amide in tetrahydrofuran T=0 - 5°C; 0.5 h; 2: With hydrogenchloride in tetrahydrofuran Further stages.;
参考文献
Vazquez, Enrique; Davies, Ian W.; Payack, Joseph F.
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7551 - 7552
反应条件
lithium diisopropyl amide in tetrahydrofuran T=0 - 20°C; 1 h;
参考文献
SANOFI; ARNAUD, Joëlle; ARTIAGA, Martine; BARTH, Francis; HORTALA, Laurent; MARTINEZ, Serge; ROUX, Pascale
Patent: WO2013/87643 A1, 2013 ;
Location in patent: Page/Page column 18 ;
