1-叔丁氧羰基-5-氯吲哚合成路线 （共 10 条）
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=25°C;
参考文献
WO2013/34048 A1, ;
Page/Page column 89; 90 ;
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate in toluene T=110°C; 16 h; Inert atmosphere;
参考文献
Tetrahedron, , vol. 66, # 33 p. 6632 - 6638
反应条件
hydrogenchloride in tetrahydrofuran Ambient temperature; Yield given;
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
1: tetrahydrofuran / Heating 2: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 5 min 3: 12N HCl / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
1: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 5 min 2: 12N HCl / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
1: tetrahydrofuran / Heating 2: 1) s-BuLi, 2) DMF / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 5 min 3: 12N HCl / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 871 - 878
反应条件
1: With tri-isopropoxy-borane; lithium diisopropyl amide in tetrahydrofuran T=0 - 5°C; 0.5 h; 2: With hydrogenchloride in tetrahydrofuran Further stages.;
参考文献
Vazquez, Enrique; Davies, Ian W.; Payack, Joseph F.
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7551 - 7552
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=0°C; 0.5 h; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
MERCK and CO., INC.
Patent: WO2006/14618 A2, 2006 ;
Location in patent: Page/Page column 34 ;
WO 2006/014618 A2
反应条件
in 2,2,2-trifluoroethanol T=150°C; 1 h; microwave irradiation;
参考文献
Synthetic Communications, , vol. 38, # 21 p. 3840 - 3853
反应条件
tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in N,N-dimethyl-formamide T=100°C; Inert atmosphere;
参考文献
MERCK SHARP and DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; DAI, Xing; LIU, Hong; HE, Shuwen; DANG, Qung
Patent: WO2013/34048 A1, 2013 ;
Location in patent: Page/Page column 90 ;
