2-碘-3,4-二甲基苯甲酸合成路线 （共 8 条）
反应条件
sulfuric acid; potassium iodide; sodium nitrite 1.) water, 10 deg C, 2.) 100 deg C; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 217 - 222
反应条件
1: With sulfuric acid; sodium nitrite in water T=0 - 2°C; 0.25 h; 2: With potassium iodide in water T=0 - 75°C;
参考文献
European Journal of Medicinal Chemistry, , vol. 37, # 10 p. 825 - 828
反应条件
1: Na2SO4, hydroxylamine sulfate, concd. HCl / H2O 2: 65 percent / CH3SO3H / 70 - 80 °C 3: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 4: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 217 - 222
反应条件
1.1: fuming HNO3 / 10 h / 0 °C 1.2: H2 / Pd-C / methanol / 10 h / 2844.31 Torr 2.1: H2SO4; NaNO2 / H2O / 0.25 h / 0 - 2 °C 2.2: KI / H2O / 0 - 75 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 37, # 10 p. 825 - 828
反应条件
1: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 2: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 217 - 222
反应条件
1: 65 percent / CH3SO3H / 70 - 80 °C 2: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 3: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 217 - 222
反应条件
1: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C 2: 70 percent / concd. H2SO4 / H2O / 0.17 h / 80 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
tri[2-(2-methoxyethoxy)ethyl]amine; copper(l) chloride in dimethyl sulfoxide T=95°C; 12 h;
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
