N-BOC-3-甲磺酰氧基哌啶合成路线 （共 12 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C; 3 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; Charrier, Jean-Damien; Durrant, Steven John; Knegtel, Ronald
Patent: US2013/115310 A1, 2013 ;
Location in patent: Paragraph 0248; 0249 ;
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran T=20°C; 16 h;
参考文献
BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; SCOTT, Daniel; CONLON, Patrick; JENKINS, Tracy, J.; POWELL, Noel; GUAN, Bing; CURERVO, Julio, H.; WANG, Deping; TAVERAS, Art
Patent: WO2012/58645 A1, 2012 ;
Location in patent: Page/Page column 210 ;
WO 2012/058645 A1
反应条件
in tetrahydrofuran; ethyl acetate
参考文献
The United States of America as represented by the Department of Health and Human Services
Patent: US5571832 A1, 1996 ;
US 5571832 A
反应条件
1: 92 percent / aq. NaHCO3 / 48 h / Ambient temperature 2: 96 percent / Et3N / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4334 - 4343
反应条件
1: 92 percent / aq. NaHCO3 / 48 h / Ambient temperature 2: 96 percent / Et3N / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4334 - 4343
反应条件
caesium carbonate in dimethyl sulfoxide T=120°C; 3 h;
参考文献
Tetrahedron, , vol. 67, # 7 p. 1485 - 1500
反应条件
caesium carbonate in dimethyl sulfoxide T=120°C;
参考文献
Tetrahedron, , vol. 67, # 7 p. 1485 - 1500
反应条件
1: 92 percent / sodium azide / dimethylformamide / 1.5 h / 100 °C 2: 95 percent / hydrogen / 5percent Pd-C / ethyl acetate / 14 h 3: 72 percent / trifluoroacetic acid / 0.67 h / Ambient temperature View Scheme
参考文献
Carbohydrate Research, , vol. 204, # 1 p. 11 - 25
反应条件
sodium azide in N,N-dimethyl-formamide T=70°C; 48 h;
参考文献
The United States of America as represented by the Department of Health and Human Services
Patent: US5571832 A1, 1996 ;
US 5571832 A
反应条件
caesium carbonate in dimethyl sulfoxide T=120°C; 3 h;
参考文献
Tetrahedron, , vol. 67, # 7 p. 1485 - 1500
