1: 1) LiHMDS, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1) THF, -78 deg C, 15 min 2) -78 to -30 deg C, 2h 2: LiOH / dioxane; H2O / 0.33 h / 25 °C View Scheme

1: 1) LiHMDS, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1) THF, -78 deg C, 15 min 2) -78 to -30 deg C, 2h 2: LiOH / dioxane; H2O / 0.33 h / 25 °C View Scheme