3-(二氟甲基)-1-甲基-1H-吡唑-5-醇合成路线 （共 7 条）
反应条件
formic acid in tert-butyl methyl ether; water T=5 - 22°C; 20 h; Product distribution / selectivity;
参考文献
BAYER CROPSCIENCE AG; PAZENOK, Sergii; MUeLLER, Michael; LUI, Norbert
Patent: WO2011/144549 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
hydrogenchloride in ethanol; water 48 h; Heating / reflux;
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY CO., LTD.
Patent: EP1364946 A1, 2003 ;
Location in patent: Page/Page column 198 ;
反应条件
hydrogenchloride in ethanol 48 h; Heating / reflux;
参考文献
Takahashi, Satoru; Ueno, Ryohei; Yamaji, Yoshihiro; Fujinami, Makoto
Patent: US2005/256004 A1, 2005 ;
Location in patent: Page/Page column 33 ;
反应条件
acetic acid in water T=5 - 22°C; 20 h;
参考文献
BAYER CROPSCIENCE AG; PAZENOK, Sergii; MUeLLER, Michael; LUI, Norbert
Patent: WO2011/144549 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
in dichloromethane 12 h;
参考文献
Hamper, Bruce C.
Journal of Fluorine Chemistry, 1990 , vol. 48, # 1 p. 123 - 131
反应条件
trichlorophosphate in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 4 h;
参考文献
Takahashi, Satoru; Ueno, Ryohei; Yamaji, Yoshihiro; Fujinami, Makoto
Patent: US2005/256004 A1, 2005 ;
Location in patent: Page/Page column 33 ;
反应条件
1: With trichlorophosphate in toluene 3 h; CoolingReflux; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
Bayer CropScience AG
Patent: US2011/207940 A1, 2011 ;
Location in patent: Page/Page column 5 ;
