1-溴-4-(2,2-二甲氧基乙氧基)苯合成路线 （共 5 条）
反应条件
potassium carbonate; potassium iodide
参考文献
GLAXOSMITHKLINE LLC; CHAUDHARI, Amita, M.; HALLMAN, Jason; LAUDEMAN, Christopher, P.; MUSSO, David, Lee; PARRISH, Cynthia, A.
Patent: WO2011/66211 A1, 2011 ;
Location in patent: Page/Page column 52 ;
WO 2011/066211 A1
反应条件
1: polyphosphoric acid / chlorobenzene 2: 45 percent / 1-methyl-pyrrolidin-2-one / 24 h / Heating View Scheme
参考文献
Journal of Materials Chemistry, , vol. 11, # 11 p. 2759 - 2772
反应条件
1: With phosphoric acid in water T=100°C; 2: With sodium carbonate in water pH=~ 7 - 8;
参考文献
GLAXOSMITHKLINE LLC; CHAUDHARI, Amita, M.; HALLMAN, Jason; LAUDEMAN, Christopher, P.; MUSSO, David, Lee; PARRISH, Cynthia, A.
Patent: WO2011/66211 A1, 2011 ;
Location in patent: Page/Page column 52 ;
WO 2011/066211 A1
反应条件
1.1: polyphosphoric acid / chlorobenzene 2.1: 45 percent / 1-methyl-pyrrolidin-2-one / 24 h / Heating 3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -90 °C 3.2: trimethyl borate / tetrahydrofuran; hexane / 0.33 h / -100 °C 3.3: 86 percent / 2 M HCl / tetrahydrofuran; hexane / -100 - 20 °C View Scheme
参考文献
Friedman; Toyne; Goodby; Hird
Journal of Materials Chemistry, 2001 , vol. 11, # 11 p. 2759 - 2772
反应条件
1.1: polyphosphoric acid / chlorobenzene 2.1: LDA / hexane; diethyl ether / 2 h / -10 °C 2.2: trimethyl borate / hexane; diethyl ether / -10 - 20 °C 2.3: 78 percent / aq. HCl / diethyl ether; hexane View Scheme
参考文献
Friedman; Toyne; Goodby; Hird
Journal of Materials Chemistry, 2001 , vol. 11, # 11 p. 2759 - 2772
